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5-Sulfosalicylic acid dihydrate

Name: 5-Sulfosalicylic acid dihydrate
Brand: SIGMA

suitable for electrophoresis, ≥99%

Synonym(s):

2-Hydroxy-5-sulfobenzoic acid

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About This Item

Linear Formula:

HO₃SC₆H₃-2-(OH)CO₂H·2H₂O

CAS Number:

5965-83-3

Molecular Weight:

254.21

UNSPSC Code:

41105319

NACRES:

NB.22

PubChem Substance ID:

24899547

EC Number:

202-555-6

Beilstein/REAXYS Number:

650741

MDL number:

MFCD00149540

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Properties

Quality Segment

200

assay

≥99%

form

powder or crystals

technique(s)

electrophoresis: suitable

impurities

≤0.02% Insoluble matter, ≤0.05% Salicylic Acid

mp

105-110 °C (lit.)

solubility

water: soluble 100 mg/mL, clear, colorless

anion traces

chloride (Cl^-): ≤0.001%, sulfate (SO₄^2-): ≤0.035%

cation traces

Fe: ≤0.001%, heavy metals (as Pb): ≤0.002%

SMILES string

[H]O[H].[H]O[H].OC(=O)c1cc(ccc1O)S(O)(=O)=O

InChI

1S/C7H6O6S.2H2O/c8-6-2-1-4(14(11,12)13)3-5(6)7(9)10;;/h1-3,8H,(H,9,10)(H,11,12,13);2*1H2

InChI key

BHDKTFQBRFWJKR-UHFFFAOYSA-N

Description

General description

5-Sulfosalicylic acid is a strong acid capable of protonating water. It forms a new theophylline complex, which was investigated by X-ray photoelectron spectroscopy (XPS). It forms 1:1 proton-transfer compounds with the ortho-substituted monocyclic heteroaromatic Lewis bases. Their crystal structures have been studied.

Application

5-Sulfosalicylic acid dihydrate may be employed for the quantification of doxorubicin derived from PEGylated liposomal doxorubicin (Doxil) and its major metabolite in human plasma by HPLC. It may be used in the preparation of poly[[tris(di-2-pyridylamine)tris([μ]-5-sulfonatosalicylato)tricopper(II)] trihydrate].

5-Sulfosalicylic acid (3.5%) in 12% trichloroacetic acid is commonly used as a fixing solution for proteins in agarose and polyacrylamide gels.

Analysis Note

Tested for use in fixing solutions for PAGE, SDS-PAGE and IEF.

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This Item	86195	S2130	247871
Sigma-Aldrich S3147 5-Sulfosalicylic acid dihydrate	Sigma-Aldrich 86195 5-Sulfosalicylic acid dihydrate	Sigma-Aldrich S2130 5-Sulfosalicylic acid dihydrate	Sigma-Aldrich 247871 2-Hydroxy-5-nitrobenzoic acid
description suitable for electrophoresis, ≥99%	description purum p.a., ≥98.0% (T)	description ReagentPlus^®, ≥99%	description 99%
technique(s) electrophoresis: suitable	technique(s) -	technique(s) -	technique(s) -
assay ≥99%	assay ≥98.0% (T)	assay ≥99%	assay 99%
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
form powder or crystals	form solid	form powder or crystals	form -
solubility water: soluble 100 mg/mL, clear, colorless	solubility water: soluble 127.1 g/L at 20 °C	solubility water: soluble 100 mg/mL, clear, colorless	solubility alcohol: freely soluble(lit.), hot water: soluble(lit.), water: soluble 1g in 1475ml(lit.), diethyl ether: freely soluble(lit.)
cation traces heavy metals (as Pb): ≤0.002%, Fe: ≤0.001%	cation traces K: ≤100 mg/kg, Ni: ≤50 mg/kg, Na: ≤100 mg/kg, Pb: ≤50 mg/kg, Cd: ≤50 mg/kg, Ca: ≤50 mg/kg, Cu: ≤50 mg/kg, Zn: ≤50 mg/kg, Fe: ≤50 mg/kg, Co: ≤50 mg/kg	cation traces -	cation traces -

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pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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