The molecular weight of methyllycaconitine is 682.80 g/mole. The molecular weight of citric acid is 192.124 g/mole. The overall molecular weight of the salt complex is 874.94 g/mole, which corresponds to 1 mole of methyllycaconitine and 1 mole of citric acid. This calculation does not account for water content or purity. The certificate of analysis provides details on the number of moles of citric acid for each lot, as well as water content and purity, which may vary from lot to lot. The free base consists of one mole of methyllycaconitine.
M168
Methyllycaconitine citrate salt
From Delphinium brownii seeds, ≥96% (HPLC), α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist
Synonym(s):
MLA, [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt
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About This Item
Empirical Formula (Hill Notation):
C37H50N2O10 · xC6H8O7
CAS Number:
Molecular Weight:
682.80 (salt-free basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥96% (HPLC)
Quality level:
Pricing and availability is not currently available.
Product Name
Methyllycaconitine citrate salt, from Delphinium brownii seeds, ≥96% (HPLC)
biological source
Delphinium brownii seeds
Quality Level
assay
≥96% (HPLC)
color
white
solubility
H2O: 42 mg/mL
storage temp.
−20°C
SMILES string
O=C(OC[C@]12[C@@]([C@]3([C@H](CC1)OC)[C@@H]4N(C2)CC)([H])[C@@H]([C@]4(O)[C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)OC)C7=CC=CC=C7N8C([C@@H](C)CC8=O)=O.OC(CC(CC(O)=O)(C(O)=O)O)=O
InChI
1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33?,34-,35+,36-,37+;/m0./s1
InChI key
INBLZNJHDLEWPS-DDIMIZGISA-N
Application
Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:
- to study its effects on inflammatory response in rats post nicotine treatment[1]
- to block the activity of galantamine[2]
- to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats[3]
Biochem/physiol Actions
Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium.[4] MLA binds to the binding site of neuronal α-bungarotoxin.[5] Low doses of MLA are associated with improvement of cognition in animals.[4]
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| assay ≥96% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level - |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. 2-8°C |
| solubility H2O: 42 mg/mL | solubility H2O: 10 mg/mL | solubility - | solubility H2O: 2 mg/mL, clear |
| color white | color white | color white to beige | color white to beige |
| biological source Delphinium brownii seeds | biological source - | biological source - | biological source - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Natalia Pinilla-Echeverri et al.
Circulation. Cardiovascular interventions, 13(7), e008768-e008768 (2020-07-11)
Complete revascularization with routine percutaneous coronary intervention of nonculprit lesions after primary percutaneous coronary intervention improves outcomes in ST-segment-elevation myocardial infarction. Whether this benefit is associated with nonculprit lesion vulnerability is unknown. In a prospective substudy of the COMPLETEs trial
Cecília Cerqueira Café-Mendes et al.
Neuroscience letters, 636, 218-224 (2016-12-17)
The hippocampus is a brain region that is rich in nicotinic acetylcholine receptors (nAChRs), especially the α7 subtype. The hippocampus is severely affected in disorders that have a neuroinflammatory component, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. Previous studies
Elizabeth Glenn Guy et al.
Psychopharmacology, 225(2), 429-440 (2012-08-14)
Stimuli associated with nicotine can become motivationally significant and may play a role in tobacco dependence. Previous work indicates that nicotine enhances responding for a conditioned reinforcer (CR). These studies examined the effects of prior exposure to nicotine on responding
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M168-5MG | 04061832082899 |
| M168-25MG | 04061834041030 |
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The COA states “1.0 mol” of salt content, is that per mole of MLA? I need to know the exact MW of the salt complex in order to make a solution of known molarity. Do I assume there is one citrate molecule for each of MLA?
1 answer-
Helpful?
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