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L3750

Sigma-Aldrich

β-Lactose

≤30% α-anomer basis, ≥99% total lactose basis

Synonym(s):

β-D-Gal-(1→4)-β-D-Glc

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About This Item

Empirical Formula (Hill Notation):
C12H22O11
CAS Number:
Molecular Weight:
342.30
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25

biological source

bovine milk

Quality Level

Assay

≥99% total lactose basis

form

powder

concentration

≥30% (α-anomer)

color

white to off-white

solubility

water: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O

InChI

1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1

InChI key

GUBGYTABKSRVRQ-DCSYEGIMSA-N

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General description

Lactose is an important disaccharide in human nutrition, culinary goods, and pharmaceuticals. β-lactose is an isomeric form that is rarely found in nature.

Application

β-Lactose has been used:
  • to treat HL-1 cells followed by phorbol dibutyrate (PDB) treatment to study if protein kinase C (PKC) -stimulated accumulation is mediated through galectin-3
  • as a component of a media to analyze the extracellular production of protein
  • along with recombinant galectin-3 to treat cells for the detection of galectin-3 cell surface binding
  • along with recombinant galectin-3 or a control protein to stimulate T cells for apoptosis assay

Biochem/physiol Actions

Beta-Lactose is the beta-pyranose form of the compound lactose.
Lactose, an excipient in a various medication, is used as an additive in a variety of foods. It is utilized as a commercial additive in the food industry due to its texture, flavor, and adhesive characteristics.

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Benjamin D Grant et al.
Analytical chemistry, 92(16), 11305-11309 (2020-07-02)
The SARS-CoV-2 pandemic has created an unprecedented need for rapid diagnostic testing to enable the efficient treatment and mitigation of COVID-19. The primary diagnostic tool currently employed is reverse transcription polymerase chain reaction (RT-PCR), which can have good sensitivity and
A tool for monitoring Trichoderma harzianum: I. Transformation with the GUS gene by protoplast technology
Thrane C, et al.
Phytopathology, 85(11), 1428-1435 (1995)
Detlef Ritter et al.
Toxicology in vitro : an international journal published in association with BIBRA, 63, 104714-104714 (2019-11-11)
Due to the increasing need of new treatment options against bacterial lung infections, novel antimicrobial peptides (AMPs) are under development. Local bioavailability and less systemic exposure lead to the inhalation route of administration. Combining AMPs with nanocarriers (NCs) into nanosystems
Preparation and characterization of high purity anhydrous beta-Lactose from alpha-Lactose monohydrate at mild temperature
Lopez-Pablos AL, et al.
International Journal of Polymer Science (2018)
Logan K Smith et al.
eLife, 10 (2021-08-10)
Despite the mechanisms of central and peripheral tolerance, the mature B cell compartment contains cells reactive for self-antigen. How these cells are poised not to respond and the mechanisms that restrain B cell responses to low-affinity endogenous antigens are not

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