For an inhibitor for beta oxidation, the following products may be of interest:
•E1905 (+)-Etomoxir sodium salt hydrate
•5.09455 InSolution Etomoxir
•M5199 Meldonium dihydrate
E1905
(+)-Etomoxir sodium salt hydrate
≥98% (HPLC), powder, CPT-1 inhibitor
Synonym(s):
R(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C15H18ClO4 · Na · H2O
CAS Number:
Molecular Weight:
338.76
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
(+)-Etomoxir sodium salt hydrate, ≥98% (HPLC), powder
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: freely soluble
storage temp.
2-8°C
SMILES string
O.[Na+].[O-]C(=O)[C@@]2(CCCCCCOc1ccc(Cl)cc1)CO2
InChI
1S/C15H19ClO4.Na.H2O/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;;/h5-8H,1-4,9-11H2,(H,17,18);;1H2/q;+1;/p-1/t15-;;/m1../s1
InChI key
WENJLJJSJDAJDN-QCUBGVIVSA-M
General description
(+)-Etomoxir sodium salt hydrate belongs to oxirane carboxylic acid group of compounds and mediates metabolic channeling of fatty acid precursors.[1] It favors oxidative stress in T cells[2] and prevents T cell differentiation.[3] It inhibits fatty acid oxidation and promotes hunger and food intake.[4] Etomoxir impairs myeloid-derived suppressor cells mediated tumor and could have potential therapeutic potential.[5]
Application
Biochem/physiol Actions
Irreversible O-carnitine palmitoyltransferase-1 (CPT-1) inhibitor; PPARα activator
Packaging
Store tightly sealed, protected from exposure to light
also commonly purchased with this product
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
OConnor RS, et al.
Scientific Reports, 8(1), 6289-6289 (2018)
Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells
Xu FY, et al.
Journal of Lipid Research, 44(2), 415-423 (2003)
Milena Schönke et al.
Journal of lipid research, 59(7), 1276-1282 (2018-05-10)
Metabolic flexibility, the capacity to adapt to fuel availability for energy production, is crucial for maintaining whole-body energy homeostasis. An inability to adequately promote FA utilization is associated with lipid accumulation in peripheral tissues and contributes to the development of
Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies
Hossain F, et al.
Cancer immunology research, 3(11), 1236-1247 (2015)
Ibrutinib Resistance Is Reduced By Fatty Acid Oxidation Inhibition In Primary CLL Lymphocytes
Galicia-Vazquez G and Aloyz R
Frontiers in Oncology, 8, 411-411 (2018)
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