C5688

Complement factor D from human plasma

90-110 μg/mL in PBS, pH 7.2, ≥90% (SDS-PAGE)

• CAS Number: 37213-56-2
• UNSPSC Code: 12352202
• NACRES: NA.61
• MDL number: MFCD00166417
• Form: liquid
• Assay: ≥90% (SDS-PAGE)
• Biological source: human plasma

Properties

• biological source: human plasma
• Quality Segment: 200
• assay: ≥90% (SDS-PAGE)
• form: liquid
• concentration: 90-110 μg/mL in PBS, pH 7.2
• UniProt accession no.: P00746
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... CFD(1675)

Description

Application

Complement factor D is a serine protease essential for the activation of the alternative pathway in the complement system. Research of complement factor D has revealed that a self inhibitory loop is responsible for switch from a resting to active state. Additionally, recent research has linked a complement factor D gene, single nucleotide polymorphism (SNP) rs3826945, with age-related macular degeneration (AMD). In these AMD cases there was a significant increase in plasma complement factor D concentration, even though previous research has shown no association between complement factor D SNP genes and AMD.

Biochem/physiol Actions

Complement factor D is a serine protease with structural homologies with chymotrypsin. In the complement cascade, factor D cleaves complement factor B in complex with activated complement component C3. It is identical to adipsin, which is expressed in adipose tissue.

Analysis Note

Source plasma tested for HBSAg, HCV, HBC, syphillis, and HIV-1/HIV-2

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable