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Amikacin sulfate salt

Name: Amikacin sulfate salt
Brand: SIGMA

aminoglycoside antibiotic

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About This Item

CAS Number:

149022-22-0

NACRES:

NA.85

PubChem Substance ID:

24890648

UNSPSC Code:

41116107

MDL number:

MFCD00167477

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Properties

biological source

synthetic

Quality Segment

200

form

powder

concentration

691-806 μg/mg (dry)

color

white to off-white

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI key

HIBICIOPDUTNRR-BOEHXBESSA-N

Description

General description

Chemical structure: aminoglycoside

Application

Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria [1]. It is used to study organism-directed delivery of antibiotics as well as drug resistance .

Biochem/physiol Actions

Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.

Antibacterial spectrum: Gram-negative and gram-positive bacteria.

Analysis Note

Amikacin:Sulfate ratio 1:1.8

Other Notes

Aminoglycoside antibiotic. Derivative of kanamycin.

Keep container tightly closed in a dry and well-ventilated place.

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This Item	A1774	A3650	B5264
Sigma-Aldrich A2324 Amikacin sulfate salt	Sigma-Aldrich A1774 Amikacin disulfate salt	Sigma-Aldrich A3650 Amikacin hydrate	Sigma-Aldrich B5264 Kanamycin B sulfate salt
mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes	mode of action protein synthesis \| interferes
antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, mycobacteria	antibiotic activity spectrum Gram-negative bacteria, mycobacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycoplasma
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder or crystals	form powder	form powder or crystals
biological source synthetic	biological source synthetic	biological source synthetic	biological source -
concentration 691-806 μg/mg (dry)	concentration -	concentration -	concentration -

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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