Key Documents

View All Documentation

Pituitary adenylate cyclase activating polypeptide-38

Name: Pituitary adenylate cyclase activating polypeptide-38
Brand: SIGMA

Synonym(s):

PACAP-38

Select a Size

Change View

Size/SKU	Availability	Price

About This Item

Empirical Formula (Hill Notation):

C₂₀₃H₃₃₁N₆₃O₅₃S

CAS Number:

137061-48-4

Molecular Weight:

4534.26

UNSPSC Code:

41106305

NACRES:

NA.32

MDL number:

MFCD00081800

Form:

powder

Pricing and availability is not currently available.

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

form

powder

Quality Segment

200

composition

Peptide content, ~70%

UniProt accession no.

P18509

storage temp.

−20°C

Gene Information

human ... ADCYAP1(116)

Description

General description

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is mapped to human chromosome 18. 27-residue-amidated fragment (PACAP27) comprises another isoform. The PACAP38 is major isoform associated with mammals.[1]

Application

Pituitary adenylate cyclase activating polypeptide-38 has been used to test its effect in stimulating the formation of cyclic AMP hypothalamus and cerebral cortex slices of chicken[2] and to treat glioblastoma cells (U87MG) in cell migration assay to test its anti-invasive effects.[3]

Biochem/physiol Actions

PACAP-38 is a neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP). It is reported to serve as a neuronal survival factor.

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a cardioprotectant and may help in treating radiation-induced heart disease (RIHD). It plays a protective role during oxidative stress in cardiomyocytes. PACAP38 has antioxidant, anti-apoptotic and anti-inflammatory property.[4] It is implicated in the pathophysiology of migraine and cluster headache.[5]

Other Notes

Lyophilized from 0.1% TFA in H2O

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	05-23-2150	F5392	P1167
Sigma-Aldrich A1439 Pituitary adenylate cyclase activating polypeptide-38	Sigma-Aldrich 05-23-2150 PACAP 38, Ovine	Sigma-Aldrich F5392 Fibroblast Growth Factor-Basic from bovine pituitary	Sigma-Aldrich P1167 Pituitary Extract bovine
form powder	form solid	form lyophilized powder	form lyophilized powder
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
Gene Information human ... ADCYAP1(116)	Gene Information -	Gene Information bovine ... FGF2(281161)	Gene Information -
composition Peptide content, ~70%	composition -	composition -	composition -
UniProt accession no. P18509	UniProt accession no. -	UniProt accession no. P03969	UniProt accession no. -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Anonymous

2 years ago

How can stock solutions for item A1439, Pituitary adenylate cyclase activating polypeptide-38, be reconstituted and stored?

1 answer
1. Technical Support
  
  2 years ago
  
  The solubility information can be found on the Specification sheet: Solubility (Solvent) Water or 1% Acetic Acid Solubility (Conc) 1.00 - 1.04 mg/ml. Stock solutions are stable for up to 3 months at -20°C.
  
  Helpful?

Reviews

No rating value