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Key Documents

P5530

Sigma-Aldrich

Phenol Red sodium salt

Powder

Synonym(s):

Phenolsulfonephthalein sodium salt

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About This Item

Empirical Formula (Hill Notation):
C19H13NaO5S
CAS Number:
Molecular Weight:
376.36
Beilstein:
6260026
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

product name

Phenol Red sodium salt, powder, BioReagent, suitable for cell culture, suitable for insect cell culture

product line

BioReagent

Quality Level

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

color

red to very dark red

visual transition interval

6.8-8.2, yellow to red

mp

285 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL

εmax

31.62 at 423 nm in 0.1 M phosphate buffer

suitability

suitable for (Suitable for use as a pH indicator)

application(s)

diagnostic assay manufacturing

storage temp.

room temp

SMILES string

[Na+].Oc1ccc(cc1)C2(OS(=O)(=O)c3ccccc23)c4ccc([O-])cc4

InChI

1S/C19H14O5S.Na/c20-15-9-5-13(6-10-15)19(14-7-11-16(21)12-8-14)17-3-1-2-4-18(17)25(22,23)24-19;/h1-12,20-21H;/q;+1/p-1

InChI key

HKHYOKBQJILTEI-UHFFFAOYSA-M

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General description

Phenol Red Sodium Salt (PRSS) is a water-soluble anionic fluorescent dye, that possesses an extra Na ion attached with the SO3 group compared to phenol red. It is intended for use in cell culture applications. A solution of phenol red will have a yellow color at a pH of 6.4 or below and a red color at a pH of 8.2 and above.

Application

The sodium salt of phenol red is used widely in culture media to identify changes from neutral to acidic pH values and as a pH marker for cell tissue culture. It is typically used in cell culture media at 11 mg/L. Phenol red in tissue culture media can act as a weak estrogen, especially in human breast cancer cells. PRSS plays a role as an indicator in the process of dying cells or overgrowth of cells in different mediums.
Suitable for use as a pH indicator.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Ulka Sachdev et al.
Molecular medicine (Cambridge, Mass.), 26(1), 69-69 (2020-07-10)
We previously showed that the autophagy inhibitor chloroquine (CQ) increases inflammatory cleaved caspase-1 activity in myocytes, and that caspase-1/11 is protective in sterile liver injury. However, the role of caspase-1/11 in the recovery of muscle from ischemia caused by peripheral

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