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09877

Sigma-Aldrich

Ammonium ionophore I

Selectophore™, function tested, ≥98.0% ((Total homologs), HPLC)

Synonym(s):

Nonactin, Ammonium ionophore

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About This Item

Empirical Formula (Hill Notation):
C40H64O12
CAS Number:
6833-84-7
Molecular Weight:
736.93
Beilstein:
76434
EC Number:
229-911-3
UNSPSC Code:
26111700
PubChem Substance ID:
24846480
NACRES:
NB.61

grade

for ion-selective electrodes

Quality Level

200

product line

Selectophore™

Assay

≥98.0% ((Total homologs), HPLC)

form

powder

quality

function tested

storage temp.

2-8°C

SMILES string

C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1

InChI

1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-

InChI key

RMIXHJPMNBXMBU-QIIXEHPYSA-N

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General description

Purified for use in ion-selective electrodes
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Application

Selected application examples
Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Transports alkali cations through biological membranes, with high selectivity for ammonia.

Legal Information

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000355383
0000324027
0000324025
0000324021
0000324031

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Y.M. Fraticelli, M.E. Meyerhoff
Analytical Chemistry, 53, 1857-1861 (1981)
D. Ammann et al.
Ion-Selective Rev., 5, 3-3 (1983)
The kinetic and equilibrium components of selective ionic permeability mediated by nactin- and valinomycin-type carriers having systematically varied degrees of methylation.
G Eisenman et al.
Annals of the New York Academy of Sciences, 264, 34-60 (1975-12-30)
Sergey M Korotkov et al.
Journal of biochemical and molecular toxicology, 21(2), 81-91 (2007-04-12)
The effects of Tl(+) ions on isolated rat liver mitochondria were studied in the presence of nonactin, a cyclic ionophore. Nonenergized rat liver mitochondria were increasingly swollen at an elevated concentration of Tl(+) in the 160 mOsm medium containing 0-150
Sarah B Luesse et al.
Bioorganic & medicinal chemistry letters, 18(14), 3946-3949 (2008-07-01)
The synthesis of a library of nonactic acid-derived triazoloamide derivatives and their evaluation as antimicrobial agents is described.
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