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JAK2 Inhibitor IV

Name: JAK2 Inhibitor IV
Brand: MM

The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

JAK2 Inhibitor IV, 3-Amino-5-(N- tert-butylsulfonamido-4-phenyl)-indazole

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₀N₄O₂S

CAS Number:

1110502-30-1

Molecular Weight:

344.43

MDL number:

MFCD16495796

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

Pricing and availability is not currently available.

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Properties

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

ethanol: 3 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NC(C)(C)C)c1ccc(cc1)c2cc3c([nH]nc3N)cc2

InChI

1S/C17H20N4O2S/c1-17(2,3)21-24(22,23)13-7-4-11(5-8-13)12-6-9-15-14(10-12)16(18)20-19-15/h4-10,21H,1-3H3,(H3,18,19,20)

InChI key

KFJCXIOVAGJCKB-UHFFFAOYSA-N

Description

General description

An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC₅₀ = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC₅₀ = 2.93 µM).

Packaging

Packaged under inert gas

Other Notes

Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett.19, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	SAB4501599	SAB4501601	HPA043870
Sigma-Aldrich 420139 JAK2 Inhibitor IV	Sigma-Aldrich SAB4501599 Anti-JAK2 antibody produced in rabbit	Sigma-Aldrich SAB4501601 Anti-JAK2 antibody produced in rabbit	Sigma-Aldrich HPA043870 Anti-JAK2 antibody produced in rabbit
description The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description affinity isolated antibody	description affinity isolated antibody	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody
assay ≥97% (HPLC)	assay -	assay -	assay -
form solid	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename -
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility DMSO: 5 mg/mL, ethanol: 3 mg/mL	solubility -	solubility -	solubility -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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