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V-011

Supelco

Retinol solution

100 μg/mL ± 25% (Refer to COA) (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, reference material, Cerilliant®

Synonym(s):

Retinol solution, 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol, Axerophthol, Vitamin A alcohol solution, Vitamin A1, all-trans-Retinol

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About This Item

Empirical Formula (Hill Notation):
C20H30O
CAS Number:
68-26-8
Molecular Weight:
286.45
Beilstein:
403040
MDL number:
MFCD00001552
UNSPSC Code:
41116107
PubChem Substance ID:
329828922
NACRES:
NA.24

grade

reference material

form

liquid

feature

(Snap-N-Shoot®)
 (Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL ± 25% (Refer to COA) (Ethanol with 0.1% (w/v) BHT)

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−70°C

SMILES string

CC(=C/CO)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

InChI key

FPIPGXGPPPQFEQ-OVSJKPMPSA-N

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Application

  • Enhancing cell culture systems: Research highlights the potential of Retinol as an essential component in cell culture systems, enhancing cell proliferation and differentiation. This supports its use in high-purity Retinol cell culture supplement applications (Ke et al., 2024).
  • Stabilized Retinol in dermatological applications: A study on topical 0.1% stabilized Bioactive Retinol demonstrates its efficacy and tolerability for treating photoaging, indicating its potential as a high-purity Retinol reagent for skin care research (Farris et al., 2024).
  • Drug-nutrient interaction research: Investigation into the interaction between Retinol and pharmaceuticals, like Acetylsalicylic Acid and Warfarin, provides insights into its role in vitamin-based assays, contributing to safer pharmacological studies involving Retinol-based assays (Renaud et al., 2024).
  • Assessment of Retinol signaling pathways: An in silico and in vitro approach examines natural ligands for receptors influenced by Retinol, aiding in the study of Retinol signaling pathways and its application as a research reagent in environmental safety (Choi et al., 2024).

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

57.2 °F

Flash Point(C)

14.0 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sarmila Mazumder et al.
Lancet (London, England), 385(9975), 1333-1342 (2014-12-17)
Vitamin A supplementation in children aged 6 months to 5 years has been shown to reduce mortality. The efficacy of neonatal supplementation with vitamin A to reduce mortality in the first 6 months of life is plausible but not established.
Gretchen A Stevens et al.
The Lancet. Global health, 3(9), e528-e536 (2015-08-16)
Vitamin A deficiency is a risk factor for blindness and for mortality from measles and diarrhoea in children aged 6-59 months. We aimed to estimate trends in the prevalence of vitamin A deficiency between 1991 and 2013 and its mortality
Malay Rana et al.
Journal of clinical pathology, 67(7), 605-608 (2014-04-09)
Determine the prevalence of fat-soluble vitamin deficiency in children with cystic fibrosis (CF) aged ≤18 years in New South Wales (NSW), Australia, from 2007 to 2010. A retrospective analysis of fat-soluble vitamin levels in children aged ≤18 years who lived in NSW
Emilie Macé et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(1), 7-16 (2014-08-07)
Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of retinal neurons mediated by adeno-associated virus (AAV) gene therapy has the potential to restore vision regardless of patient-specific mutations. The challenge for clinical
Koji Hiraoka et al.
Biochemical and biophysical research communications, 460(2), 216-221 (2015-03-17)
LGR5 plays an important role in the self-renewal of stem cells and is used as a marker identifying self-renewing stem cells in small intestine and hair follicles. Moreover, LGR5 has been reported to be overexpressed in several cancers. SOX9 is
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Protocols

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

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