The purity of this material is indicated by the dye content. The minimum dye content of this product is 65%. A brief review of recent lots indicates that 85 - 90% dye content is typical. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/543/093/t3516pis.pdf
T3516
Thioflavin T
Powder
Synonym(s):
Basic Yellow 1, Thioflavine T
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All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C17H19ClN2S
CAS Number:
Molecular Weight:
318.86
Colour Index Number:
49005
Beilstein:
3922452
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
Pricing and availability is not currently available.
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Product Name
Thioflavin T, used as stain for amyloid
form
powder
composition
Dye content, ≥65%
solubility
methanol: 1 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
[Cl-].CN(C)c1ccc(cc1)-c2sc3cc(C)ccc3[n+]2C
InChI
1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChI key
JADVWWSKYZXRGX-UHFFFAOYSA-M
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General description
Application
Thioflavin T has been used to identify the presence of amyloid fibrils in samples.[4]
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Sens. 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Customers Also Viewed
Matthew Biancalana et al.
Biochimica et biophysica acta, 1804(7), 1405-1412 (2010-04-20)
Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since its first description in 1959, the fluorescent dye Thioflavin-T (ThT) has become among the most
Jian Xiong et al.
Biophysical chemistry, 220, 42-48 (2016-11-20)
The hydrophobic fragment of the Alzheimer's related β-amyloid (Aβ) peptide, Aβ(25-40), aggregates and forms insoluble amyloid fibrils at a rate similar to the full-length peptide. In order to gain insight into the fibrillization of Aβ(25-40) and the ability of the
Ljiljana Sjekloća et al.
Cell chemical biology, 26(8), 1159-1168 (2019-06-11)
Thioflavin T (ThT) is widely used for the detection of amyloids. Many unrelated DNAs and RNAs that contain G-quadruplex motifs also bind ThT and strongly activate its fluorescence. To elucidate the structural basis of ThT binding to G quadruplexes and
Rashmi S Tupe et al.
Pharmaceutical biology, 55(1), 68-75 (2016-09-10)
Protein glycation is the major contributing factor in the development of diabetic complications. The antiglycation potential of medicinal plants provides a promising opportunity as complementary interventions for complications. To investigate the antiglycation potential of 19 medicinal plants extracts using albumin
Ritu Khurana et al.
Journal of structural biology, 151(3), 229-238 (2005-08-30)
Thioflavin T is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, thioflavin T was found to exist as micelles
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How do you reconsititute the powder?
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As described in the product data sheet, the product is soluble in methanol at 1mg/mL (0.1% w/v).
Please see the product data sheet for additional solubility and handling recommendations: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/543/093/t3516pis.pdfHelpful?
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