SML2027
L-2-oxothiazolidine-4-carboxylic acid propargyl amide
≥98% (HPLC)
Synonym(s):
(R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide, OTC propargyl amide, OTC-PA
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About This Item
Empirical Formula (Hill Notation):
C7H8N2O2S
CAS Number:
Molecular Weight:
184.22
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
C#CCNC([C@@H]1CSC(N1)=O)=O
Biochem/physiol Actions
L-2-oxothiazolidine-4-carboxylic acid propargyl amide is a cell penetrant, potent and selective competitive inhibitor of cystathionine-γ-lyase that completely abrogated L-cysteine-induced vasorelaxation in tissue.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Angela Corvino et al.
Scientific reports, 6, 34398-34398 (2016-10-07)
Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis. It is endogenously synthesized mainly by two pyridoxal-5'-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ß-synthase (CBS) and cystathionine-γ-lyase (CSE). Research
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