Syntaxin 1 is a membrane protein. It is also known as HPC-1. Neurons express syntaxin 1A.
Immunogen
highly purified GST fusion protein with the residues 1-265 of rat syntaxin 1A (intracellular, N-terminal).
Application
Anti-Syntaxin 1 antibody has been used in western blotting and immunohistochemistry.
Biochem/physiol Actions
Syntaxin 1 (STX1A) may control exocytosis in synaptic vesicles. In retina, STX1A may help in the structural formation of the INL (inner nuclear layer) and OPL(outer plexiform layer). Deletion of STX1A in mice affects the functions of hypothalamic-pituitary-adrenal axis. It may participate in spinal nociceptive plasticity promoted by peripheral nerve injury.
Physical form
After reconstitution, the antibody solution is phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The European journal of neuroscience, 36(9), 3152-3164 (2012-09-06)
Directed cell migration and axonal guidance are essential steps in neural development that share many molecular mechanisms. The guidance of developing axons and migrating neurons is likely to depend on the precise control of plasmalemma turnover in selected regions of
Unusual retinal layer organization in HPC-1/syntaxin 1A knockout mice
Kaneko Y, et al.
Journal of Molecular Histology, 42(5), 483-489 (2011)
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