75447
2-Oxoadipic acid
≥95.0% (HPLC)
Synonym(s):
α-Ketoadipic acid, 2-Oxoadipate, 2-Oxohexanedioic acid
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About This Item
Empirical Formula (Hill Notation):
C6H8O5
CAS Number:
Molecular Weight:
160.12
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25
Pricing and availability is not currently available.
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Assay
≥95.0% (HPLC)
≥97.0% (T)
form
powder
lipid type
saturated FAs
storage temp.
2-8°C
SMILES string
OC(=O)CCCC(=O)C(O)=O
InChI
1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)
InChI key
FGSBNBBHOZHUBO-UHFFFAOYSA-N
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Application
- Engineering of phenylalanine dehydrogenase from Thermoactinomyces intermedius for the production of a novel homoglutamate: Showcases the application of 2-oxoadipic acid in enzyme engineering, enhancing biocatalytic processes for the production of novel compounds, vital for pharmaceutical and chemical industries (Tariq et al., 2022).
Biochem/physiol Actions
Important metabolite between the TCA cycle and lysine biosynthesis. Of interest for research on mitochondrial metabolite transporters.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Iwona Gabriel et al.
FEMS yeast research, 13(2), 143-155 (2012-10-31)
The LYS12 gene from Candida albicans, coding for homoisocitrate dehydrogenase was cloned and expressed as a His-tagged protein in Escherichia coli. The purified gene product catalyzes the Mg(2+)- and K(+)-dependent oxidative decarboxylation of homoisocitrate to α-ketoadipate. The recombinant enzyme demonstrates
alpha-Aminoadipic and alpha-ketoadipic aciduria: detection of a new case by a screening program using two-dimensional thin layer chromatography of amino acids.
C Vianey-Liaud et al.
Journal of inherited metabolic disease, 8 Suppl 2, 133-134 (1985-01-01)
S A Osmani et al.
European journal of biochemistry, 147(1), 119-128 (1985-02-15)
Cell-free extracts of Rhizopus arrhizus contain exclusively cytosolic pyruvate carboxylase and NAD-glutamate dehydrogenase, a single mitochondrial isoenzyme of NADP-isocitrate dehydrogenase, and both mitochondrial and cytosolic isoenzymes of NADP-malate dehydrogenase (decarboxylating). Other enzymes examined have sub-cellular localisations similar to those characteristic
R Lukacin et al.
European journal of biochemistry, 249(3), 748-757 (1997-12-12)
Flavanone 3beta-hydroxylase, involved in the biosynthesis of flavonoids, catechins, and anthocyanidins, is a non-heme iron enzyme, dependent on Fe2+, molecular oxygen, 2-oxoglutarate, and ascorbate, the typical cofactors of the class of 2-oxoglutarate-dependent dioxygenases. Sequence alignment analysis of various 2-oxoglutarate-dependent dioxygenases
A patient with alpha-ketoadipic and alpha-aminoadipic aciduria.
M Duran et al.
Journal of inherited metabolic disease, 7(2), 61-61 (1984-01-01)
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