14-439-M
MAP Kinase 1/Erk1 Protein, active, 10 µg
Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.
Synonym(s):
ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32
Pricing and availability is not currently available.
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biological source
human
Quality Level
recombinant
expressed in E. coli
form
liquid
mol wt
Mw 69.9 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
color
colorless
solubility
water: soluble
NCBI accession no.
UniProt accession no.
Gene Information
human ... MAPK3(5595)
General description
Research area: Cell Signaling
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Biochem/physiol Actions
Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control.[1] Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle.[2] MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.[3]
Packaging
Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.
Quality
routinely evaluated by phosphorylation of MBP
Physical form
Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)
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