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N-907

Supelco

Nortriptyline hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C19H22ClN
CAS Number:
894-71-3
Molecular Weight:
299.84
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

InChI key

SHAYBENGXDALFF-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A4(6532)

General description

Nortriptyline is a second generation tricyclic antidepressant (TCA) marketed under trade names such as Sensoval, Aventyl®, and Pamelor® for treatment of major depression. Nortriptyline is also an active metabolite of the TCA amitriptyline. This certified Snap-N-Spike® solution is suitable for LC/MS or GC/MS applications in clinical toxicology, forensic analysis, urine drug testing, or medication monitoring applications.

Application


  • Neuropharmacological research: A study explored the effectiveness of antidepressants in combination with psychotherapy, including nortriptyline hydrochloride. This research emphasizes its role in treating mental health disorders, showcasing the compound′s importance in neuropharmacological research and its potential for further exploration in neurotransmitter studies (Alemi et al., 2024).

  • Peripheral neuropathy treatment: Nortriptyline hydrochloride was evaluated for its efficacy in managing diabetic peripheral neuropathy, highlighting its therapeutic benefits beyond traditional antidepressant applications. This study underlines its utility in biochemical assays aimed at understanding its mechanism of action on neurophysiological pathways (Bragg et al., 2024).

Legal Information

Aventyl is a registered trademark of Eli Lilly and Co.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Pamelor is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Karim Malki et al.
Pharmacogenetics and genomics, 22(11), 765-776 (2012-10-03)
Monoaminergic imbalances play a role in the pathogenesis of depression and most common antidepressant drugs act on monoamine neurotransmitters. However, the lag time between restoring neurochemical balance and symptom improvement suggests that the response to drugs involves complex biological events
Chiara Vladiskovic et al.
Journal of pharmaceutical sciences, 101(12), 4481-4489 (2012-09-19)
Nortriptyline hydrochloride, a tricyclic antidepressant, appears in two different polymorphic forms, only one of which (hereafter, form β) has been previously characterized by single-crystal analysis. Form β is monoclinic, P2(1)/c, with a = 5.070(2), b = 34.088(5), c = 9.976(1)
Escitalopram versus nortriptyline: how to let the clinical GENDEP data tell us what they contained.
P Bech et al.
Acta psychiatrica Scandinavica, 127(4), 328-329 (2013-03-14)
Robert A Power et al.
Journal of psychiatric research, 46(10), 1333-1338 (2012-07-10)
Most comparisons of the efficacy of antidepressants have relied on the assumption that missing data are randomly distributed. Dropout rates differ between drugs, suggesting this assumption may not hold true. This paper examines the effect of non-random dropout on a
Matthew T Olson et al.
Clinical chemistry, 59(6), 920-927 (2013-02-22)
The addition of a calibration curve with every run is both time-consuming and expensive for clinical mass spectrometry assays. We present alternative calibration strategies that eliminate the need for a calibration curve except as required by laboratory regulations. We measured
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