791268P
Avanti
DTPA-BSA (Gd)
DTPA-bis(stearylamide) (gadolinium salt), powder
Synonym(s):
(diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt); Gd-DTPA-BSA
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About This Item
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 mg (791268P-100mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 791268P
shipped in
dry ice
storage temp.
−20°C
General description
DTPA-BSA (Gd) (diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt)) is an amphiphilic molecule with paramagnetic property.
Application
DTPA-BSA (Gd) (diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt)) has been used:
- in the preparation of nontargeting (NT) gadolinium peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) of atherosclerotic lesions
- as a MRI agent in the preparation of lipid-like nanoparticles (LLNs) for small interfering RNA (siRNA) encapsulation
- as a MRI agent in the preparation of paramagnetic saposin C and dioleylphosphatidylserine (SapC-DOPS) vesicles for imaging glioblastoma multiforme (GBM) tumors
Biochem/physiol Actions
Gd-DTPA-BSA is useful as magnetic resonance imaging (MRI) agent and the gadolinium ion enables the generation of bright images by lowering the longitudinal relaxation time.
Packaging
5 mL Amber Glass Screw Cap Vial (791268P-100mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Journal of magnetic resonance imaging : JMRI, 41(4), 1079-1087 (2014-05-07)
To investigate paramagnetic saposin C and dioleylphosphatidylserine (SapC-DOPS) vesicles as a targeted contrast agent for imaging phosphatidylserine (PS) expressed by glioblastoma multiforme (GBM) tumors. Gd-DTPA-BSA/SapC-DOPS vesicles were formulated, and the vesicle diameter and relaxivity were measured. Targeting of Gd-DTPA-BSA/SapC-DOPS vesicles
ACS omega, 1(5), 996-1003 (2016-12-06)
The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by
Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents
Nanoscale, 9(4), 1575-1579 (2017)
Imaging of brain tumors with paramagnetic vesicles targeted to phosphatidylserine
Journal of Magnetic Resonance Imaging : JMRI, 41(4), 1079-1087 (2015)
Gadolinium-functionalized peptide amphiphile micelles for multimodal imaging of atherosclerotic lesions
ACS Omega, 1(5), 996-1003 (2016)
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