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270873

Sigma-Aldrich

2-Hydroxyquinoline

98%

Synonym(s):

2-Quinolinol, Carbostyril

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About This Item

Empirical Formula (Hill Notation):
C9H7NO
CAS Number:
59-31-4
Molecular Weight:
145.16
EC Number:
200-420-6
MDL number:
MFCD00006743
UNSPSC Code:
12352100
PubChem Substance ID:
24856409
NACRES:
NA.22

Assay

98%

form

crystals

mp

198-199 °C (lit.)

solubility

alcohol: soluble(lit.)
diethyl ether: soluble(lit.)
dilute HCl: soluble(lit.)
water: slightly soluble (1 g/950mL)(lit.)

SMILES string

Oc1ccc2ccccc2n1

InChI

1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)

InChI key

LISFMEBWQUVKPJ-UHFFFAOYSA-N

General description

2-Hydroxyquinoline is a specific inhibitor of plaque paraoxonase1 (PON1).

Application

2-Hydroxyquinoline was used to obtain the design of the platinum(IV) complexes with intense bands shifted towards longer wavelengths. The Pt(IV) complexes are inert stable prodrugs that were photoactivated to produce Pt(II) species with promising anticancer activity.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H318,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alexander J Bones et al.
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Cryptosporidium is a genus of single celled parasites capable of infecting a wide range of animals including humans. Cryptosporidium species are members of the phylum apicomplexa, which includes well-known genera such as Plasmodium and Toxoplasma. Cryptosporidium parasites cause a severe
Elad Cohen et al.
Journal of lipids, 2012, 762560-762560 (2012-06-13)
Human carotid plaque components interact directly with circulating blood elements and thus they might affect each other. We determined plaque paraoxonase1 (PON1) hydrolytic-catalytic activity and compared plaque and blood levels of lipids, HDL, PON1, and HbA1c, as well as plaque-oxidized
Edyta Stec et al.
Chembiochem : a European journal of chemical biology, 12(11), 1724-1730 (2011-06-15)
Aurachins are quinoline alkaloids isolated from the myxobacterium Stigmatella aurantiaca. They are substituted with an isoprenoid side chain and act as potent inhibitors in the electron transport chain. A biosynthetic gene cluster that contains at least five genes (auaA-auaE) has
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