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X4879

Sigma-Aldrich

Xaliproden hydrochloride

≥97% (HPLC), solid

Synonym(s):

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

Empirical Formula (Hill Notation):
C24H22F3N · HCl
CAS Number:
90494-79-4
Molecular Weight:
417.89
MDL number:
MFCD00896209
UNSPSC Code:
12352200
PubChem Substance ID:
329830807
NACRES:
NA.77

Assay

≥97% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

InChI key

WVHBEIJGAINUBW-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

Biochem/physiol Actions

5-HT1A serotonin receptor agonist; neuroprotectant

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effects of paliroden (SR57667B) and xaliproden on adult brain neurogenesis.
C Labie et al.
Current Alzheimer research, 3(1), 35-36 (2006-02-14)
Lucette Lacomblez et al.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 5(2), 99-106 (2004-06-19)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. We report the safety and functional efficacy results of a double-blind, placebo-controlled phase II study of xaliproden, a non-peptidic compound with growth factor activities, in 54 ALS patients
Paul H Gordon et al.
Archives of neurology, 66(6), 758-761 (2009-06-10)
To examine how respiratory interventions affect survival as an outcome measure and to define survival rate for trials in amyotrophic lateral sclerosis. We reviewed the data of 3 phase 3 clinical trials and examined differences in times to death, tracheostomy
What we have learned from the Xaliproden Sanofi-aventis trials.
P Douillet et al.
The journal of nutrition, health & aging, 13(4), 365-366 (2009-03-21)
Sherry Wolf et al.
European journal of cancer (Oxford, England : 1990), 44(11), 1507-1515 (2008-06-24)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side effect of many commonly used chemotherapeutic agents, including platinum drugs, taxanes, epothilones and vinca alkaloids, and also newer agents such as bortezomib and lenolidamide. Symptom control studies have been conducted
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