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G8146

Sigma-Aldrich

Disialoganglioside GD1b from bovine brain

~95%, lyophilized powder

Synonym(s):

Ganglioside GD1b, disialo

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About This Item

CAS Number:
19553-76-5
MDL number:
MFCD00466941
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

~95%

Quality Level

200

form

lyophilized powder

storage temp.

−20°C

InChI

1S/C80H144N4O37/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-54(96)83-36-49(44(91)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)111-74-65(104)63(102)67(52(40-88)114-74)116-76-66(105)72(68(53(41-89)115-76)117-73-57(84-43(3)90)71(61(100)51(39-87)112-73)118-75-64(103)62(101)60(99)50(38-86)113-75)121-80(78(108)109)35-46(93)56(82)70(120-80)59(98)48(95)42-110-79(77(106)107)34-45(92)55(81)69(119-79)58(97)47(94)37-85/h30,32,44-53,55-76,85-89,91-95,97-105H,4-29,31,33-42,81-82H2,1-3H3,(H,83,96)(H,84,90)(H,106,107)(H,108,109)/b32-30+/t44?,45-,46+,47?,48?,49?,50+,51+,52-,53+,55+,56-,57+,58?,59?,60-,61-,62-,63-,64+,65-,66+,67-,68-,69+,70-,71+,72+,73-,74-,75-,76-,79-,80-/m1/s1

InChI key

AIUBMTQAHKTQMI-MPGPKOMUSA-N

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Amino Acid Sequence

Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S Tellier et al.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 19(1), 51-54 (2011-12-14)
We describe the case of a 10-year-old child with the acute motor axonal neuropathy (AMAN) form of Guillain-Barré syndrome (GBS) with preserved tendon reflexes, 6 days after a bout of gastroenteritis. The child quickly showed weakness of the distal muscles
An unusual presentation of Guillain-Barré syndrome associated with monospecific anti-GD1b antibodies.
Maarten Dewil et al.
Journal of neurology, neurosurgery, and psychiatry, 81(5), 587-588 (2010-05-13)
Jing-Xia Liu et al.
Investigative ophthalmology & visual science, 50(7), 3226-3232 (2009-03-04)
To examine the distribution of anti-GQ1b, -GT1a, and -GD1b antibody binding in human extraocular muscles (EOMs), axial and limb muscles, and muscle spindles and thereby test the hypothesis that their distinctive ganglioside composition provides the molecular basis for selective involvement
Ricardo D Lardone et al.
Journal of neurology, neurosurgery, and psychiatry, 81(6), 629-633 (2009-12-08)
Clinical severity of Guillain-Barré syndrome (GBS) is highly variable, but the immunopathological reason is unknown. The study was designed to show which antibody parameters are associated with disease severity in GBS patients with serum anti-GM1 IgG antibodies. Thirty-four GBS patients
Beatriz Valle-Argos et al.
Neuro-oncology, 12(11), 1135-1146 (2010-07-10)
In spite of their low incidence, central nervous system tumors have elevated morbidity and mortality, being responsible for 2.3% of total cancer deaths. The ganglioside O-acetylated GD1b (O-Ac GD1b; neurostatin), present in the mammalian brain, and the semi-synthetic O-butyrylated GD1b
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