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56834

Sigma-Aldrich

Immunoglobulin G from human serum

≥95% (GE)

Synonym(s):

Human IgG

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About This Item

MDL number:
MFCD00163923
UNSPSC Code:
12352203
NACRES:
NA.46

Quality Level

100

Assay

≥95% (GE)

form

fibers

technique(s)

radioimmunoassay: suitable

impurities

≤1.0% sodium
≤15% water

solubility

0.1 M NaCl: 10 mg/mL, clear to slightly turbid, colorless

storage temp.

2-8°C

General description

Immunoglobulin G (IgG) subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids. IgG provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections
Human IgG is purified from normal human serum and contains =1.0% sodium and =15% water.

Application

Immunoglobulin G from human serum may be used as a standard in solid-phase RIA, and to ensure precipitation in RIA for acetylcholine receptor and anti-acetylcholine receptor antibody. It may be used in preparation of soluble antigen containing tyrosine residues for iodination.

Other Notes

Review

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Use of solid-phase radioimmunoassay specific for human IgG or human C3b to detect Fc gamma or C3b receptors on human lymphoblastoid cell surfaces.
R Frade et al.
Methods in enzymology, 93, 155-163 (1983-01-01)
Suicide of lymphoid cells.
A Basten et al.
Methods in enzymology, 108, 254-261 (1984-01-01)
V Cabiaux et al.
Biophysical journal, 73(1), 406-417 (1997-07-01)
Aquaporins are integral membrane proteins found in diverse animal and plant tissues that mediate the permeability of plasma membranes to water molecules. Projection maps of two-dimensional crystals of aquaporin-1 (AQP1) reconstituted in lipid membranes suggested the presence of six to
Immunoglobulin G (IgG).
P D Gorevic et al.
Methods in enzymology, 116, 3-25 (1985-01-01)
Laura R Stingaciu et al.
Scientific reports, 6, 22148-22148 (2016-03-30)
A flexible linker region between three fragments allows antibodies to adjust their binding sites to an antigen or receptor. Using Neutron Spin Echo Spectroscopy we observed fragment motion on a timescale of 7 ns with motional amplitudes of about 1
View All Related Papers

Protocols

HPLC Analysis of Immunoglobulin G (IgG) on Zenix® SEC-150 versus Zenix® SEC-300, Effect of Pore Size on Resolution

HPLC Analysis of Immunoglobulin G (IgG) on Zenix® SEC-150 versus Zenix® SEC-300, Effect of Pore Size on Resolution

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