15862

Cobalt chloride 0.1 M solution

• Synonym(s): Cobalt(II)-chloride solution, Additive Screening Solution 24/Kit-No 78374
• CAS Number: 7646-79-9
• MDL number: MFCD00010938
• UNSPSC Code: 12352302
• PubChem Substance ID: 57647530
• NACRES: NA.32

Properties

• density: 1.01 g/mL at 20 °C
• storage temp.: 2-8°C
• SMILES string: Cl[Co]Cl
• InChI: 1S/2ClH.Co/h2*1H;/q;;+2/p-2
• InChI key: GVPFVAHMJGGAJG-UHFFFAOYSA-L

Description

Application

Cobalt chloride 0.1M solution has been used to simulate hypoxic exposure and HIF-1 (hypoxia-inducible factor 1) expression in prostate cancer cells. It has been used to induce hypoxia in human intestinal epithelial cells.

Biochem/physiol Actions

Cobalt chloride induces hypoxia condition in cells by upregulating hypoxia-inducible factor-1α (HIF-1α), erythropoietin and glycolytic enzymes. It is also responsible for mitochondrial DNA damage in rat neuronal PC12 cells. It is also responsible for the induction of apoptosis.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Safety Information

• Pictograms: GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H350,H360F,H411
• Precautionary Statements: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Carc. 1B - Repr. 1B
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves