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511075

Sigma-Aldrich

Platelet Activating Factor-16

≥98% (TLC), lyophilized solid, inflammation mediator, Calbiochem®

Synonym(s):

Platelet Activating Factor-16, PAF (C₁₆), 1-O-Palmityl-2-acetyl- sn-glycero-3-phosphocholine, 1-O-Hexadecyl-2-acetyl- sn-glycero-3-phosphocholine, PAF (C₁₆), 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C26H54NO7P
CAS Number:
74389-68-7
Molecular Weight:
523.68
UNSPSC Code:
12352211
NACRES:
NA.77

product name

Platelet Activating Factor-16, A potent mediator of inflammation that increases vascular permeability. Activates MAP kinases and MAP kinase kinase (MEK) in CHO cells.

Quality Level

100

Assay

≥98% (TLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white to off-white

solubility

ethanol: 0.5-1 mg/mL
water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

InChI key

HVAUUPRFYPCOCA-AREMUKBSSA-N

General description

Synthetic water-soluble platelet activating factor. A potent mediator of inflammation that increases vascular permeability. Activates MAP kinase and MAP kinase kinase (MEK) in CHO cells.
Synthetic. A potent mediator of inflammation that increases vascular permeability. Activates MAP kinases and MAP kinase kinase (MEK) in CHO cells.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MAP kinases and MAP kinase kinase (MEK)
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C or -70°C) under an inert gas. Aqueous stock solutions are stable for up to 3 days at -20°C. Ethanol stock solutions are stable for up to 3 months at -70°C.

Other Notes

Honda, Z., et al. 1994. J. Biol. Chem. 269, 2307.
Mori, M., et al. 1994. Ann. N.Y. Acad. Sci.744, 107.
Pinckard, R.N., et al. 1992. J. Immunol.148, 3528.
Salari, H., et al. 1992. Biochem. Cell Biol.70, 129.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Emily A Henderson et al.
Frontiers in immunology, 15, 1363962-1363962 (2024-03-22)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer associated with an immunosuppressive environment. Neutrophil extracellular traps (NETs) were initially described in the context of infection but have more recently been implicated in contributing to the tolerogenic immune response in PDAC.
R H Adamson et al.
American journal of physiology. Heart and circulatory physiology, 285(1), H406-H417 (2003-03-22)
We tested the hypothesis that acutely induced hyperpermeability is dependent on actin-myosin contractility by using individually perfused mesentery venules of pentobarbital-anesthetized rats. Venule hydraulic conductivity (Lp) was measured to monitor hyperpermeability response to the platelet-activating factor (PAF) 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine or bradykinin.

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