N-906

Nitrazepam solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₅H₁₁N₃O₃
• CAS Number: 146-22-5
• Molecular Weight: 281.27
• EC Number: 200-835-2
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• concentration: 1.0 mg/mL in acetonitrile
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3)c2c1
• InChI: 1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)
• InChI key: KJONHKAYOJNZEC-UHFFFAOYSA-N

Description

General description

A certified solution standard suitable for use as starting material in calibrators and controls of nitrazepam for LC/MS or GC/MS testing methods. Nitrazepam is a benzodiazepine sold as a treatment for severe insomnia. This drug is marketed under the trade names Mogadon, Nitrados, and Somnite.

Application

• Nitrazepam research solution in sedative pharmacological studies: Nitrazepam, a benzodiazepine, is extensively used in pharmacological research focusing on its sedative effects. Studies explore its impact on the central nervous system and its potential therapeutic applications for sleep disorders and anxiety (Bhoir et al., 1999).
• Neuroscientific research applications of Nitrazepam: The solution is vital in neuroscientific studies, particularly those investigating the modulation of GABAergic systems by benzodiazepines. Nitrazepam is used to elucidate the mechanisms through which benzodiazepines affect neurotransmitter release and neuronal excitability (Honeychurch et al., 2006).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2 °C - closed cup