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918970

Sigma-Aldrich

VincePhos

≥95%

Synonym(s):

7,7,9,9-Tetramethyl-8-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)-1,4-dioxa-8-phosphaspiro[4.5]decane

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About This Item

Empirical Formula (Hill Notation):
C34H51O4P
CAS Number:
Molecular Weight:
554.74
UNSPSC Code:
12352112
NACRES:
NA.22

Quality Level

Assay

≥95%

form

powder

reaction suitability

reagent type: catalyst
reaction type: Cross Couplings

reagent type: ligand

functional group

phosphine

storage temp.

−20°C

Application

VincePhos is a biaryl phosphorinane ligand for Pd catalysis. This ligand has been used in a variety of Pd-catalyzed reactions including the sulfonamidation of aryl halides, C-O couplings, and C-N couplings.

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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David M Barnes et al.
The Journal of organic chemistry, 84(8), 4873-4892 (2019-01-11)
Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed. First, the copper-catalyzed
Pd-Catalyzed Cross-Coupling Reactions Promoted by Biaryl Phosphorinane Ligands.
Laffoon S D, et al.
ACS Catalysis, 9(12), 11691-11708 (2019)

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