Z3003

Zardaverine

powder, ≥98% (HPLC)

• Synonym(s): 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone
• Empirical Formula (Hill Notation): C₁₂H₁₀F₂N₂O₃
• CAS Number: 101975-10-4
• Molecular Weight: 268.22
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278784
• NACRES: NA.77
• MDL number: MFCD00867059

Properties

• Product Name: Zardaverine,
• Quality Segment: 200
• SMILES string: COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
• InChI: 1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
• InChI key: HJMQDJPMQIHLPB-UHFFFAOYSA-N
• Gene Information: human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150) ; rat ... Pde2a(81743), Pde4a(25638)

Description

Application

Zardaverine has been used as a phosphodiesterase inhibitor:

• to study its effects on human colonic epithelial cells
• to study its effects on junctional proteins in Sertoli cells
• to study its effects on phosphodiesterase 3 A (PDE3A) expression in various tumor cells

Biochem/physiol Actions

Zardaverine is a derivative of pyridazinone. It shows anti-tumor and anti-proliferative activity in varied cell lines. Zardaverine possesses broncho-dilatory activity and exhibits therapeutic effects against asthma.

Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)