SML2918

INT131

≥98% (HPLC)

• Synonym(s): 2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide, AMG-131, T0903131
• Empirical Formula (Hill Notation): C₂₁H₁₂Cl₄N₂O₃S
• CAS Number: 315224-26-1
• Molecular Weight: 514.21
• MDL number: MFCD13152369
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• InChI: 1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
• InChI key: NMRWDFUZLLQSBN-UHFFFAOYSA-N

Description

Biochem/physiol Actions

INT131 is a brain penetrant, non-thiazolidinedione, highly potent and selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator (SPPARM) that displays anti-diabetic activities. INT131 is a partial, rather than a full agonist of PPARγ, and in clinical trials has shown increased glucose tolerance without the weight gain and cardiovascular side effects seen with some of the full agonist.

Safety Information

• Storage Class Code: 11 - Combustible Solids