A8231

AGK2

≥97% (HPLC), powder

• Synonym(s): 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
• Empirical Formula (Hill Notation): C₂₃H₁₃Cl₂N₃O₂
• CAS Number: 304896-28-4
• Molecular Weight: 434.27
• MDL number: MFCD01909444
• UNSPSC Code: 12352200
• PubChem Substance ID: 329770953
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: powder
• solubility: DMSO: 2 mg/mL, clear (warmed); H₂O: insoluble
• storage temp.: room temp
• SMILES string: Clc1ccc(Cl)c(c1)-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2
• InChI: 1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
• InChI key: SVENPFFEMUOOGK-SDNWHVSQSA-N

Description

Application

AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Biochem/physiol Actions

AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves