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120M-8

Sigma-Aldrich

CD20 (L26) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

L26, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (120M-84)
vial of 0.5 mL concentrate (120M-85)
bottle of 1.0 mL predilute (120M-87)
vial of 1.0 mL concentrate (120M-86)
bottle of 7.0 mL predilute (120M-88)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG2aκ

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... MS4A1(931)

General description

Anti-CD20 (B-cell Pan) reacts with a membrane antigen that is present in B-cells. This antibody recognizes Reed-Sternberg cells, predominant in Hodgkin′s disease, in a minority of cases. Since no staining of histiocytes or plasma cells has been observed and CD20 has not been detected in T-cell malignancies, it is a very strong marker of B-cell lymphomas. Anti-CD20 does not cross-react with non-hematopoetic neoplasms.

Quality


IVD
IVD
IVD
RUO

Linkage

CD20 Positive Control Slides, Product No. 120S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alexandar Tzankov et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 9(4), 1381-1386 (2003-04-10)
Recent evidence has demonstrated that classical Hodgkin lymphoma (cHL) originates from mature germinal center B cells. However, only approximately 25% of cHLs express the classical B-cell marker CD20. There is very little, and controversial, information on the prognostic significance of
F R Davey et al.
The American journal of pathology, 129(1), 54-63 (1987-10-01)
The use of monoclonal and polyclonal antibodies for the immunophenotyping of non-Hodgkin's lymphomas in paraffin-embedded tissue has been limited by the fact that most antigens on lymphoid cells are denatured by histologic fixation, dehydration, and embedment. In this article the
Y Ishii et al.
Clinical and experimental immunology, 58(1), 183-192 (1984-10-01)
Two distinct antigen systems (L26 and L27) specifically expressed in human B lymphocytes were identified using TB2-2B3 (2B3) and T3-5B3 (5B3) monoclonal antibodies, respectively. Whereas L26 antigen defined by 2B3 were rarely expressed on the surface of B cells but
A new look at lymphoma immunohistology.
D Y Mason
The American journal of pathology, 128(1), 1-4 (1987-07-01)
Patrick Browne et al.
American journal of clinical pathology, 120(5), 767-777 (2003-11-12)
Even with routine immunohistochemical evaluation, distinguishing classic Hodgkin lymphoma (CHL) from diffuse large B-cell lymphoma (DLBCL) or anaplastic large cell lymphoma (ALCL) can be difficult. In these cases, the transcription factors (B cell-specific activator protein [BSAP], octamer-binding transcription factor 2

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