If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
PHR1061
Valproic acid
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
2-Propylpentanoic acid, 2-Propylvaleric acid, Valproic acid
About This Item
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to Ph. Eur. V0033000
traceable to USP 1708707
API family
valproic acid
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
refractive index
n20/D 1.425 (lit.)
bp
220 °C (lit.)
density
0.9 g/mL at 25 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
CCCC(C(O)=O)CCC
InChI
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
InChI key
NIJJYAXOARWZEE-UHFFFAOYSA-N
Gene Information
human ... ALDH5A1(7915)
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General description
Application
Biochem/physiol Actions
Analysis Note
Other Notes
Footnote
Recommended products
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
231.8 °F - closed cup
Flash Point(C)
111 °C - closed cup
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Customers Also Viewed
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Could you please provide me with information regarding the solvent used to dissolve this product and the final concentration of valproic acid in 1G pack (as g/ml) Additionally, I would like to know if valproic acid available for purchase in powder form
1 answer-
In the pure form, Valproic acid exists as a neat liquid, the concentration will be considered 100%. The density of the pure form is 0.905 g/mL at 20 °C. The solubility is not tested, however literature shows that it is only slightly soluble in water - 1.3 - 2.0 mg/mL. It is freely soluble in organic solvents, acids and bases. The salt forms are available as powders. Please see the links below to review additional solubility information available at PubChem, as well as a link to the powder form of this product.
PubChem - see section 3:
https://pubchem.ncbi.nlm.nih.gov/compound/Valproic-Acid#section=SolubilityValproic acid sodium salt:
https://www.sigmaaldrich.com/US/en/product/sigma/p4543Helpful?
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Is it necessary to dissolve in any solvent (like water or serum physiologic) for administration to rats intraperitoneally. Or can it be applied directly?
1 answer-
Valproic acid is reportedly water soluble at 50 mg/mL. However, this product has not been tested for in vivo or in vitro use. This product is not sterile, suitability would have to be determined by the end-user.
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