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BCR096

Dibenzo[a,l]pyrene

BCR®, certified reference material

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About This Item

Empirical Formula (Hill Notation):
C24H14
CAS Number:
191-30-0
Molecular Weight:
302.37
Beilstein:
2054068
MDL number:
MFCD00467035
UNSPSC Code:
41116107
PubChem Substance ID:
329774220
NACRES:
NA.24

grade

certified reference material

Agency

BCR®

manufacturer/tradename

JRC

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

SMILES string

c1ccc2c(c1)cc3ccc4cccc5c6ccccc6c2c3c45

InChI

1S/C24H14/c1-2-8-18-16(6-1)14-17-13-12-15-7-5-11-20-19-9-3-4-10-21(19)24(18)23(17)22(15)20/h1-14H

InChI key

JNTHRSHGARDABO-UHFFFAOYSA-N

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Analysis Note

For more information please see:
BCR096

Legal Information

BCR is a registered trademark of European Commission

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H318,H341,H350

Hazard Classifications

Carc. 1B - Eye Dam. 1 - Muta. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Yuqin Cai et al.
Biochemistry, 49(46), 9943-9945 (2010-10-23)
The impact of a bulky DNA lesion on the structure and dynamics of a nucleosome core particle (NCP) containing a lesion derived from the unusually potent tumorigen dibenzo[a,l]pyrene that resists nucleotide excision repair (NER) in free DNA was investigated using
Yijin Tang et al.
Biochemistry, 51(48), 9751-9762 (2012-11-06)
The most potent tumorigen identified among the polycyclic aromatic hydrocarbons (PAH) is the nonplanar fjord region dibenzo[a,l]pyrene (DB[a,l]P). It is metabolically activated in vivo through the widely studied diol epoxide (DE) pathway to form covalent adducts with DNA bases, predominantly
Shang-Min Zhang et al.
Chemical research in toxicology, 24(8), 1297-1303 (2011-07-09)
Tobacco smoking is one of the leading causes for oral cancer. Dibenzo[a,l]pyrene (DB[a,l]P), an environmental pollutant and a tobacco smoke constituent, is the most carcinogenic polycyclic aromatic hydrocarbon (PAH) tested to date in several animal models (target organs: skin, lung
Tammie J McQuistan et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(2), 341-352 (2011-11-15)
Recent pilot studies found natural chlorophyll (Chl) to inhibit carcinogen uptake and tumorigenesis in rodent and fish models, and to alter uptake and biodistribution of trace (14)C-aflatoxin B1 in human volunteers. The present study extends these promising findings, using a
Lyndsey E Shorey et al.
Cancer letters, 317(1), 49-55 (2011-11-17)
Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established
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