539164
Proteasome Inhibitor Set I
The Proteasome Inhibitor Set I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
About This Item
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Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
shipped in
ambient
storage temp.
−20°C
General description
The ubiquitin-proteasome pathway plays a major role in the breakdown of abnormal proteins that result from oxidative stress and mutations that might otherwise disrupt normal cellular homeostasis. The reactive oxygen species can promote partial unfolding of the proteins, exposing its hydrophobic domains to proteolytic enzymes of the 20S complex. Rapid degradation of defective enzymes, as seen in diseases caused by metabolic abnormalities, also occurs in the proteasome. The Ubq-proteasome pathway has also been implicated in several forms of malignancy, in the pathogenesis of several genetic diseases, and in the pathology of muscle wasting. It is also involved in the destruction of proteins that participate in cell cycle progression, transcription control, signal transduction, and metabolic regulation.
Biochem/physiol Actions
MPC
NF-κB activity
Warning
Other Notes
Griscavage, J.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 3308.
Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.
Oda, K., et al. 1996. Biochem. Biophys. Res. Commun.219, 800.
Fenteany, G., et al. 1995. Science268, 726.
Traenckner, E.B., et al. 1994. EMBO J.13, 5433.
Legal Information
Storage Class Code
11 - Combustible Solids
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Select different protease inhibitor types based on your needs to prevent protein degradation during isolation and characterization and safeguard proteins in sample prep.
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