700021P

27-hydroxycholesterol

Avanti Research^™ - A Croda Brand

• Synonym(s): 27-hydroxycholesterol(25R); cholest-5-ene-3β,27-diol, (25R); 110818
• Empirical Formula (Hill Notation): C₂₇H₄₆O₂
• CAS Number: 20380-11-4
• Molecular Weight: 402.65
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• description: cholest-(25R)-5-ene-3β,27-diol
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (700021P-1mg); pkg of 1 × 25 mg (700021P-25mg); pkg of 1 × 5 mg (700021P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• InChI key: FYHRJWMENCALJY-YSQMORBQSA-N

Description

General description

27-hydroxycholesterol (27-HC) is synthesized from cholesterol by the action of sterol 27-hydroxylase in liver. It is an abundant oxysterol in the circulation ranging from 0.15 to 0.73 μM. 27-HC serves as a substrate for bile synthesis.

Application

27-hydroxycholesterol has been used:

• to test its inhibitory effect on hepatic lipid accumulation
• as liver X receptor (LXR) ligand in breast cancer cell lines
• as a control in liquid chromatography with tandem mass spectrometry (LC-MS-MS) for the quantitation of 25-OHC in jejunum samples

Biochem/physiol Actions

27-hydroxycholesterol (27-HC) is a weak liver X receptor (LXR) agonist and a selective estrogen receptor modulator (SERM). Elevated levels of 27-HC is observed in hypercholesterolemia. 27-HC is implicated in breast cancer tumor and glioblastoma progression. 27-HC may help in treating non-alcoholic steatohepatitis. Elevated levels of 27-HC is associated with atherosclerotic lesions.

Packaging

5 mL Amber Glass Screw Cap Vial (700021P-1mg)

5 mL Amber Glass Screw Cap Vial (700021P-25mg)

5 mL Amber Glass Screw Cap Vial (700021P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable