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901594

Sigma-Aldrich

Diisopropylcarbodiimide solution

1 M in THF

Synonym(s):

Diisopropylmethanediimine

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About This Item

Linear Formula:
C7H14N2
CAS Number:
693-13-0
MDL number:
MFCD00065689
UNSPSC Code:
12352111
NACRES:
NA.22

form

liquid

reaction suitability

reaction type: Coupling Reactions

concentration

1 M in THF

density

0.870 g/mL

application(s)

peptide synthesis

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

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Application

Coupling reagent for peptide syntheses.
DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Valuable reagent offered as a solution in tetrahydrofuran for more convenient handling.

related product

Product No.
Description
Pricing

38370

DIC, purum, ≥98.0% (GC)

D125407

DIC, 99%

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

2.0 °F

Flash Point(C)

-16.66 °C

Certificates of Analysis (COA)

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J Izdebski et al.
International journal of peptide and protein research, 43(2), 184-189 (1994-02-01)
Alkoxycarbonylamino acid symmetrical anhydrides were allowed to react with N,N'-diisopropylcarbodiimide. The determination of the decrease in carbodiimide concentration indicated that the reaction was slow and proceeded indirectly. It is presumed that symmetrical anhydride in the presence of basic carbodiimide is
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