394866

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

synthesis grade

• Synonym(s): N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA
• Linear Formula: CF₃CON(CH₃)Si(CH₃)₃
• CAS Number: 24589-78-4
• Molecular Weight: 199.25
• Beilstein: 1941550
• EC Number: 246-331-6
• MDL number: MFCD00000411
• UNSPSC Code: 12000000
• PubChem Substance ID: 24864622
• NACRES: NA.22

Properties

• grade: for GC derivatization; synthesis grade
• vapor density: >1 (vs air)
• vapor pressure: 8.8 mmHg ( 27 °C)
• Assay: ≥98%
• form: liquid
• reaction suitability: reagent type: derivatization reagent; reaction type: Silylations
• refractive index: n20/D 1.38 (lit.)
• bp: 130-132 °C (lit.)
• density: 1.075 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CN(C(=O)C(F)(F)F)[Si](C)(C)C
• InChI: 1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3
• InChI key: MSPCIZMDDUQPGJ-UHFFFAOYSA-N

Description

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Application

Silylating agent used to form volatile derivatives for GC-MS analysis.
Improved silylation procedure for simultaneous detection of steroid hormones 17-α-ethynylestradiol and estrone.

Other Notes

Reagent for trimethylsilyl.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Warning
• Hazard Statements: H226,H315,H319,H335
• Precautionary Statements: P210 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 78.8 °F - closed cup
• Flash Point(C): 26 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves