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Sigma-Aldrich

(−)-Methyl L-lactate

greener alternative

98%, optical purity ee: 97% (GLC)

Synonym(s):

Methyl (S)-(−)-lactate

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About This Item

Linear Formula:
CH3CH(OH)CO2CH3
CAS Number:
Molecular Weight:
104.10
Beilstein:
1720587
EC Number:
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

liquid

optical activity

[α]18/D −8.1°, neat

optical purity

ee: 97% (GLC)

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

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refractive index

n20/D 1.413 (lit.)

bp

144-145 °C (lit.)

density

1.09 g/mL at 25 °C (lit.)

greener alternative category

SMILES string

COC(=O)[C@H](C)O

InChI

1S/C4H8O3/c1-3(5)4(6)7-2/h3,5H,1-2H3/t3-/m0/s1

InChI key

LPEKGGXMPWTOCB-VKHMYHEASA-N

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General description

(-)-Methyl L-lactate can be used as a chiral auxiliary during the synthesis of Bao Gong Teng A, an antiglaucoma compound.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry.This compound has benign qualities and is biodegradable, water miscible, and functions as a versatile solvent for CA membrane preparation. This is also used as an intermediate for the production of other chemicals, polymers, and derivatives. Thus this product has been enhanced for Safer solvents and auxiliaries. Click here for more information.

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

120.2 °F - closed cup

Flash Point(C)

49 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Methyl (S)-lactate as a chiral auxiliary in the asymmetric synthesis of Bao Gong Teng A.
Pham VC and Charlton JL.
The Journal of Organic Chemistry, 60(24), 8051-8055 (1995)
K Le Barbu-Debus et al.
Physical chemistry chemical physics : PCCP, 11(35), 7589-7598 (2009-12-03)
Complexation between (1R,2S)-(+)-cis-1-amino-2-indanol (AI) and the two enantiomers of methyl lactate has been studied by means of laser-induced fluorescence, resonance-enhanced two-photon ionisation, and IR-UV double resonance spectroscopy, in the region of 3 microm. Two isomeric complexes have been spectroscopically characterised
Katia Le Barbu-Debus et al.
Physical chemistry chemical physics : PCCP, 8(8), 1001-1006 (2006-02-17)
Two low energy conformers of the chiral (R)-1-aminoindan molecule are identified in supersonic jet and their ground and excited states vibrational spectroscopy has been investigated by laser-induced fluorescence (LIF) excitation and single vibronic level (SVL) emission spectroscopy. Ab initio calculations
Opposite signs of capacitive microsensor signals upon exposure to the enantiomers of methyl propionate compounds.
Petra Kurzawski et al.
Angewandte Chemie (International ed. in English), 47(5), 913-916 (2007-12-22)
K Bodenhöfer et al.
Nature, 387(6633), 577-580 (1997-06-05)
Odour perception in humans can sometimes discriminate different enantiomers of a chiral compound, such as limonene. Chiral discrimination represents one of the greatest challenges in attempts to devise selective and sensitive gas sensors. The importance of such discrimination for pharmacology

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