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18565

Sigma-Aldrich

Bromotripyrrolidinophosphonium hexafluorophosphate

≥95.0% (HPLC), for peptide synthesis

Synonym(s):

PyBroP®

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About This Item

Empirical Formula (Hill Notation):
C12H24BrF6N3P2
CAS Number:
132705-51-2
Molecular Weight:
466.18
Beilstein:
6842340
MDL number:
MFCD00077412
UNSPSC Code:
12352107
PubChem Substance ID:
57647747
NACRES:
NA.22

product name

Bromotripyrrolidinophosphonium hexafluorophosphate, ≥95.0% (HPLC)

Assay

≥95.0% (HPLC)

form

solid

reaction suitability

reaction type: Coupling Reactions

application(s)

peptide synthesis

storage temp.

−20°C

SMILES string

F[P-](F)(F)(F)(F)F.Br[P+](N1CCCC1)(N2CCCC2)N3CCCC3

InChI

1S/C12H24BrN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1

InChI key

CYKRMWNZYOIJCH-UHFFFAOYSA-N

Application

Catalyst for:
Synthesis of primary amides
Direct dehydrative phosphonium cross coupling
Direct arylation
Pyrrolidide formation by phosphonium salt coupling reagents
It can be used as a coupling reagent:
  • For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls.
  • To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles.
  • To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine.

It can also be used as an activating reagent:
  • For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes.
  • For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.

Other Notes

Reactive peptide coupling reagent suitable for α,α-dialkyl amino acids; Synthesis of depsipeptides

Legal Information

PyBroP is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ni-catalyzed construction of C-P bonds from electron-deficient phenols via the in situ aryl C-O activation by PyBroP.
Zhao YL, et al.
Chemical Communications (Cambridge, England), 48(47), 5868-5870 (2012)
Efficient Pd-Catalyzed Coupling of Tautomerizable Heterocycles with Terminal Alkynes via C-OH Bond Activation Using PyBrOP.
Shi C and Aldrich CC
Organic Letters, 12(10), 2286-2289 (2010)
Efficient Conversion of Biginelli 3, 4-Dihydropyrimidin-2 (1 H)-one to Pyrimidines via PyBroP-Mediated Coupling.
Kang FA, et al.
The Journal of Organic Chemistry, 70(5), 1957-1960 (2005)
PyBroP: a convenient activator for the synthesis of formamidines.
Delarue S and Sergheraert C
Tetrahedron Letters, 40(30), 5487-5490 (1999)
Nickel-Catalyzed Cross-Coupling of Phenols and Arylboronic Acids Through an In Situ Phenol Activation Mediated by PyBroP.
Chen GJ, et al.
Chemistry?A European Journal , 17(14), 4038-4042 (2011)
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