U2875

Uric acid sodium salt

• Synonym(s): 2,6,8-Trihydroxypurine, Sodium acid urate
• Linear Formula: C₅H₃N₄O₃Na
• CAS Number: 1198-77-2
• Molecular Weight: 190.09
• EC Number: 214-838-1
• MDL number: MFCD00067310
• UNSPSC Code: 41106305
• PubChem Substance ID: 24900636
• NACRES: NA.51

Properties

• biological source: microbial; synthetic
• Assay: 11.0-13.0% anhydrous basis (Sodium, ICP)
• form: powder
• solubility: 1 M NaOH: 25 mg/mL, clear, colorless to faintly yellow
• SMILES string: [Na].O=C1NC(=O)C2=C(N1)NC(=O)N2
• InChI: 1S/C5H4N4O3.Na.H/c10-3-1-2(7-4(11)6-1)8-5(12)9-3;;/h(H4,6,7,8,9,10,11,12);;
• InChI key: IHMJZGFANDMEJM-UHFFFAOYSA-N

Description

Application

Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

Biochem/physiol Actions

Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid. Sodium urate has been shown to precipitate calcium oxalate from urine. It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity. Excess sodium urate in soft tissues results in a condition referred to as tophi.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves