SML2401

Imeglimin hydrochloride

≥98% (HPLC), powder, anti-hyperglycemic compound

• Synonym(s): (6R)-1,6-dihydro-N,N,6-trimethyl-1,3,5-Triazine-2,4-diamine Hydrochloride,, (6R)-3,6-Dihydro-N2,N2,6-trimethyl-1,3,5-triazine-2,4-diamine, EMD 387008 Hydrochloride, EMD-387008 Hydrochloride, R-(4-Imino-6-methyl-1,4,5,6-tetrahydro-[1,3,5]trazin-2-yl)dimethylamine Hydrochloride
• Empirical Formula (Hill Notation): C₆H₁₃N₅ · xHCl
• CAS Number: 775351-61-6
• Molecular Weight: 155.20 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Imeglimin hydrochloride, ≥98% (HPLC)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Cl.N1[C@@H](N=C(N=C1N(C)C)N)C
• InChI: 1S/C6H13N5.ClH/c1-4-8-5(7)10-6(9-4)11(2)3;/h4H,1-3H3,(H3,7,8,9,10);1H/t4-;/m1./s1
• InChI key: UXHLCYMTNMEXKZ-PGMHMLKASA-N

Description

Biochem/physiol Actions

Glucose-lowering agent that appears to target mitochondrial bioenergetics

Imeglimin is a first-in-class oral glucose-lowering agent whose mechanism of action targets mitochondrial bioenergetics, resulting in increased insulin secretion in response to glucose, improved glucose uptake by skeletal muscle, and suppression of gluconeogenesis. Imeglimin has been shown to decrease reactive oxygen species overproduction and delay mPTP opening, preventing cell death during oxidative stress, protecting beta-cells. In an animal model, it has been shown to reduce metabolic syndrome-related diabetic cardiomyopathy.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable