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Key Documents

SAB5702238

Sigma-Aldrich

Anti-PD-L1/CD274 Antibody, clone 8F1V6, Rabbit Monoclonal

Synonym(s):

B7-H,B7H1,PDL1,PD-L1,PDCD1L1,PDCD1LG1,CD274

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

biological source

rabbit

Quality Level

material

colorless

clone

8F1V6, monoclonal

form

liquid

species reactivity

human

concentration

0.65 mg/mL

technique(s)

flow cytometry: 1:50 - 1:200

color

colorless

isotype

IgG

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PD-L1(29126)

General description

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.

Immunogen

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Recombinant protein of human PD-L1/CD274.

Application

ELISA, WB, FC, Inhibition

Storage Class Code

10 - Combustible liquids

WGK

WGK 1


Certificates of Analysis (COA)

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