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Key Documents

SAB5200035

Sigma-Aldrich

Monoclonal Anti-HCN4 antibody produced in mouse

clone S114-10, 1 mg/mL, purified immunoglobulin

Synonym(s):

Anti-HCN4, S141-10, Anti-hyperpolarization activated cyclic nucleotide gated potassium channel 4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S114-10, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 130 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_067690.1

UniProt accession no.

Q9Y3Q4

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... HCN4(59266)

Related Categories

General description

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4) is one of the subunits of hyperpolarization-activated cyclic nucleotide-gated channels, which have a role in synaptic transmission, dendritic integration, membrane and action potential. It is a heteromeric channel. HCN4 is highly expressed in rat embryonic hearts, specifically in the sinoatrial node.

Specificity

Detects ~130 kDa. No cross-reactivity against other HCNs

Immunogen

Fusion protein amino acids 1019-1198 (c-terminus) of rat HCN4, Accession Number Q9JKA7

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.
Hughes DI
Neuroscience (2013)
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Zhang Q
Biochimica et Biophysica Acta (2009)
Valentina Prando et al.
The Journal of physiology, 596(11), 2055-2075 (2018-03-11)
The present study demonstrates, by in vitro and in vivo analyses, the novel concept that signal transmission between sympathetic neurons and the heart, underlying the physiological regulation of cardiac function, operates in a quasi-synaptic fashion. This is a result of
Jingyun Dong et al.
Pacing and clinical electrophysiology : PACE, 42(2), 275-282 (2018-12-24)
The HCN4 gene encodes a subunit of the hyperpolarization-activated cyclic nucleotide-gated channel, type 4 that is essential for the proper generation of pacemaker potentials in the sinoatrial node. The HCN4 gene is often present in targeted genetic testing panels for
Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
Milanesi R
The New England Journal of Medicine (2006)
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