SAB2900181
Anti-FAP (AB1) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
170-kDa melanoma membrane-bound gelatinase, FAP, FAP alpha, FAPA, Seprase, fibroblast activation protein, fibroblast activation protein alpha
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: 10-20 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FAP(2191)
General description
FAP gene is localized on human chromosome 2q24.2.
Fibroblast activation protein (FAP) is a type II transmembrane serine protease and a cell surface antigen. It is present as a homodimeric integral protein with dipeptidyl peptidase IV like fold. FAP has an α/β-hydrolase domain and an eight-bladed β-propeller domain. It is not expressed in normal tissues. The protein is only expressed by activated fibroblasts in response to pathologic situations.
Immunogen
Synthetic 18 amino acid peptide from extracellular domain of human FAP. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Bovine (89%); Marmoset (83%).
Application
Anti-FAP (AB1) antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Fibroblast activation protein (FAP) is expressed in several pathogenic sites including cancer, fibrosis, arthritis, wounding, or inflammation. FAP has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Dipeptidyl peptidase (DPP) 4 (CD26, DPP4) is a multi-functional protein involved in T cell activation by co-stimulation via its association with adenosine deaminase (ADA), caveolin-1, CARMA-1, CD45, mannose-6-phosphate/insulin growth factor-II receptor (M6P/IGFII-R) and C-X-C motif receptor 4 (CXC-R4). The proline-specific
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