S2071

Anti-Sodium Channel Na_V1.8 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-PN3, Anti-SCN10A
• MDL number: MFCD08705520
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat
• technique(s): immunohistochemistry (frozen sections): suitable using adult rat DRG; western blot: 1:200 using rat DRG lysates
• UniProt accession no.: Q62968
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SCN10A(6336) ; mouse ... Scn10a(20264) ; rat ... Scn10a(29571)

Description

General description

Sodium voltage-gated channel α subunit 10 (SCN10A) codes for Nav1.8 sodium channels. It is expressed in nociceptive neurons. This gene is mapped to human chromosome 3p22.2.

Immunogen

peptide (C)EDEVAAKEGNSPGPQ corresponding to residues 1943-1957 of rat Na_v1.8. This sequence has 14/15 residues identical in mouse and 7/15 residues identical in human.

Application

Anti-Sodium Channel NaV1.8 antibody has been used in immunohistochemistry and immunocytochemistry.

Biochem/physiol Actions

Sodium voltage-gated channel α subunit 10 (SCN10A) plays a major role in human pain. It is involved in the pathophysiology of cerebellar deficits in MS (multiple sclerosis).

Target description

Anti-Sodium Channel Na_V1.8 specifically recognizes Na_V1.8. Voltage-gated sodium channels (VGSCs) are present in most excitable cells. They play a crucial role in regulating the cell excitability, being primarily responsible for the

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05 % sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable