P8390

Picrotoxinin

• Empirical Formula (Hill Notation): C₁₅H₁₆O₆
• CAS Number: 17617-45-7
• Molecular Weight: 292.28
• MDL number: MFCD00078765
• UNSPSC Code: 41116107
• PubChem Substance ID: 24898746
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• SMILES string: [H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C
• InChI: 1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1
• InChI key: PIMZUZSSNYHVCU-KBLUICEQSA-N

Description

General description

Picrotoxinin is a component of picrotoxin and can be derived from plants. It is a non-nitrogenous compound.

Application

Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay and to study the effect of calcium buffering and calcium sensor type on its sensitivity.

Biochem/physiol Actions

Picrotoxinin acts as a potent convulsant.

GABA_A receptor antagonist; binds to the GABA receptor-linked Cl⁻ channel.

Features and Benefits

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This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Active component of picrotoxin

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves