M3281

α-Methyl-DL-tyrosine methyl ester hydrochloride

≥95% (HPLC)

• Synonym(s): α-MT methyl ester hydrochloride, 2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride, AMPT methyl ester hydrochloride
• Linear Formula: 4-(HO)C₆H₄CH₂C(CH₃)(NH₂)CO₂CH₃ · HCl
• CAS Number: 7361-31-1
• Molecular Weight: 245.70
• Beilstein: 5163031
• EC Number: 230-900-0
• MDL number: MFCD00012606
• UNSPSC Code: 12352108
• PubChem Substance ID: 24278548
• NACRES: NA.32

Properties

• Assay: ≥95% (HPLC)
• mp: 192 °C (dec.) (lit.)
• solubility: DMSO: ≥20 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1
• InChI: 1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H
• InChI key: OOVDEPZODSXAMU-UHFFFAOYSA-N
• Gene Information: human ... TH(7054)

Description

Application

α-Methyl-DL-tyrosine methyl ester hydrochloride has been used to evaluate norepinephrine turnover.

Biochem/physiol Actions

α-Methyl-DL-tyrosine (α-MT) prevents hyperactivity, sniffing-licking-gnawing syndrome, anorexia and ameliorates certain effects of amphetamine. It inhibits dopamine production and prevents apoptosis stimulated by mutant α-synuclein.

Tyrosine hydroxylase inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves