Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
A4978
Alendronate sodium trihydrate
≥97% (NMR), powder
Synonym(s):
4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217
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About This Item
Empirical Formula (Hill Notation):
C4H12NaNO7P2 · 3 H2O
CAS Number:
Molecular Weight:
325.12
MDL number:
UNSPSC Code:
41106300
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Assay
≥97% (NMR)
form
powder
color
white
solubility
water, double-distilled: 10 mg/mL
storage temp.
−20°C
SMILES string
[Na+].[H]O[H].[H]O[H].[H]O[H].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
InChI
1S/C4H13NO7P2.Na.3H2O/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;3*1H2/q;+1;;;/p-1
InChI key
DCSBSVSZJRSITC-UHFFFAOYSA-M
Gene Information
human ... FDPS(2224)
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Application
Alendronate sodium trihydrate has been used:
- for calcium phosphate nanoparticles (nCaP)/ bisphosphonate (BP) coating on titanium implants and analyze its osteogenic capacity
- in osteogenic differentiation of human bone marrow stromal cells (hBMSCs) isolated from aged osteoporosis patients- and healthy-person
- to treat osteoblast progenitor cells and osteoblasts and study their effect on osteoblast behaviors using conventional assays and simple digital image analysis[1]
Biochem/physiol Actions
Alendronate is a nitrogen-containing bisphosphonate[1] that is known to hinder the mevalonate pathway and limit osteoclastic function and activity. Alendronate sodium trihydrate is a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor, and CD45 protein tyrosine phosphatase inhibitor.
Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.
Storage and Stability
Following reconstitution, it is recommended to aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Xuefeng Hu et al.
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Fibrous encapsulation can impair implant osseointegration and cause implant failure but currently there are limited strategies to address this problem. Since bisphosphonates (BPs), a class of drugs widely used to treat bone diseases, was recently found to induce fibroblast apoptosis
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Journal of immunology (Baltimore, Md. : 1950), 191(6), 2879-2889 (2013-08-13)
Bisphosphonates (BPs) have been widely used to treat osteoporosis. They act by inhibiting farnesyl diphosphate synthase in the mevalonate pathway. This resembles the action of statins, whose immune-modulating effect has recently been highlighted. In contrast, the effect of BPs on
Young-Pil Yun et al.
Journal of biomedical nanotechnology, 10(6), 1080-1090 (2014-04-23)
The osteogenic effect of culturing adipose-derived stem cells (ADSCs) on alendronate (Aln)-loaded polycarprolactone (PCL) nanofibrous scaffolds was evaluated by examining alkaline phosphatase (ALP) activity, calcium content, and expression of osteogenic differentiation genes in vitro. The 10% Aln/PCL nanofibrous scaffolds showed
Núria Guañabens et al.
Hepatology (Baltimore, Md.), 58(6), 2070-2078 (2013-05-21)
Osteoporosis resulting in bone fractures is a complication in patients with primary biliary cirrhosis (PBC). Once-weekly alendronate improves bone mass and is well tolerated in these patients, but there is a concern because of poor compliance. Therefore, the efficacy, adherence
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After diluting in H2O, under what conditions should the solution be stored and what is the shelf-life?
1 answer-
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What quality control assays are typically done on Product A4978, Alendronate sodium trihydrate?
1 answer-
The assays typically done on Product No. A4978 are appearance, solubility, elemental analysis for carbon, hydrogen and nitrogen (CHN) and proton NMR (1H-NMR) spectroscopy. The results of these assays may be found on the certificate of analysis for each lot.
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I see that Product A4978, Alendronate sodium trihydrate, is a trihydrate. How was the water content determined?
1 answer-
Our supplier typically determines the water content by a loss on drying. We have not tested the water content in our labs here at Sigma by that method; we typically confirm the supplier’s value by CHN (elemental analysis for carbon, hydrogen and nitrogen, comparing the measured values to the theoretical values for the trihydrate).
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How should I dissolve Product A4978, Alendronate sodium trihydrate?
1 answer-
This product is soluble in water at a concentration of 10 mg/mL.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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