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M8054

Sigma-Aldrich

Manganese(II) chloride tetrahydrate

meets USP testing specifications

Synonym(s):

Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O

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About This Item

Linear Formula:
MnCl2 · 4H2O
CAS Number:
Molecular Weight:
197.91
EC Number:
MDL number:
UNSPSC Code:
12352302
PubChem Substance ID:
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

Quality Level

Assay

98.0-101.0% dry basis

form

flakes

mp

58 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

InChI key

CNFDGXZLMLFIJV-UHFFFAOYSA-L

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2

Target Organs

Brain

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Lisha Luo et al.
NMR in biomedicine, 25(12), 1360-1368 (2012-05-11)
The aim of this study was to provide data on the dose dependence of manganese-enhanced MRI (MEMRI) in the visual pathway of experimental rats and to study the toxicity of MnCl₂ to the retina. Sprague-Dawley rats were intravitreally injected with
Geoffrey J Topping et al.
Medical physics, 40(4), 042502-042502 (2013-04-06)
Manganese(II) is employed as a contrast agent with magnetic resonance imaging (MRI) for study of neuronal activation in rats and mice. However, at the concentrations required for MRI, Mn may induce pharmacological or toxic effects. Positron emission tomography (PET) imaging
Tameshwar Ganesh et al.
Journal of magnetic resonance imaging : JMRI, 41(3), 806-813 (2014-03-05)
To investigate the potential of manganese (Mn)-enhanced MRI for sensitive detection and delineation of tumors that demonstrate little enhancement on Gd-DTPA. Eighteen nude rats bearing 1 to 2 cm in diameter orthotopic breast tumors (ZR75 and LM2) were imaged on
Marta Sidoryk-Wegrzynowicz et al.
Journal of neurochemistry, 122(4), 856-867 (2012-06-20)
Manganese (Mn) has been implicated in the impairment of the glutamate-glutamine cycling (GGC) by deregulation of Glu and glutamine (Gln) turnover in astrocytes. Here, we have examined possible mechanisms involved in the Mn(II)-mediated disruption of Glu turnover, including those related
A G Kanthasamy et al.
Toxicology letters, 214(3), 288-295 (2012-09-22)
The role of normal cellular prion protein (PrP) remains to be fully elucidated; however, the protein is crucial for the infection and progression of prion diseases. Recent evidence indicates that PrP is a metalloprotein since the octapeptide repeat sequences in

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