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N-036

Supelco

(±)-Norketamine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C12H15Cl2NO
CAS Number:
79499-59-5
Molecular Weight:
260.16
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

Cl.NC1(CCCCC1=O)c2ccccc2Cl

InChI

1S/C12H14ClNO.ClH/c13-10-6-2-1-5-9(10)12(14)8-4-3-7-11(12)15;/h1-2,5-6H,3-4,7-8,14H2;1H

InChI key

CLPOJGPBUGCUKT-UHFFFAOYSA-N

General description

Norketamine is the major urinary metabolite of ketamine. This certified Snap-N-Spike® Solution is suitable for numerous GC/MS or LC/MS applications in forensic analysis, urine drug testing, clinical toxicology, and clinical or diagnostic testing. Ketamine, sold as Ketanest®, Ketaset® and Ketalar®, is an NMDA receptor antagonist used for the induction and maintenance of general anesthesia in human and veterinary medicine. The drug is often abused at clubs, raves, or parties for its noted hallucingenic and dissociative properties and prescribed by some doctors as an off-label treatment for depression.

Application


  • Pharmacokinetics of ketamine following a short intravenous infusion to isoflurane-anesthetized New Zealand White rabbits: This study employs (±)-Norketamine hydrochloride to examine the pharmacokinetics of ketamine, providing critical insights into its metabolic pathways and implications for anesthetic use in veterinary medicine (Luca et al., 2020).

  • Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy: Research utilizing (±)-Norketamine hydrochloride explores its pharmacological properties compared to ketamine, enhancing the understanding of its safety and efficacy in clinical settings, which is crucial for the development of anesthetic protocols (Wang et al., 2019).

  • The acute and residual effects of escalating, analgesic-range doses of ketamine on driving performance: This innovative study leverages (±)-Norketamine hydrochloride to investigate the effects of ketamine on motor skills and cognitive functions, contributing to discussions on public safety and clinical use of psychoactive compounds (Hayley et al., 2018).

  • Ketamine metabolites with antidepressant effects: This research highlights the role of (±)-Norketamine hydrochloride in identifying ketamine metabolites with potential antidepressant effects, thus expanding its applications beyond anesthetic use to potentially treat mood disorders (Fassauer et al., 2017).

  • Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs: Utilizing (±)-Norketamine hydrochloride, this study aims at developing new ketamine analogs that could offer benefits such as reduced side effects and shorter duration of action, pivotal for both clinical and therapeutic applications (Harvey et al., 2015).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Ketalar is a registered trademark of Par Sterile Products, LLC
Ketanest is a registered trademark of Pfizer, Inc.
Ketaset is a registered trademark of Zoetis W LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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D-046

Dehydronorketamine hydrochloride solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

K-002

Ketamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

K-003

Ketamine-D4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-037

(±)-Norketamine-D4 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

H-134

Hydroxynorketamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®

E-144

N-Ethyldeschloroketamine hydrochloride solution, 1 mg/mL in methanol ((as free base)), certified reference material, ampule of 1 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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