International journal of nanomedicine, 7, 4037-4051 (2012-08-14)
We designed dual-functional nanoparticles for in vivo application using a modified electrostatic and covalent layer-by-layer assembly strategy to address the challenge of assessment and treatment of hormone-refractory prostate cancer. Core-shell nanoparticles were formulated by integrating three distinct functional components, ie
Langmuir : the ACS journal of surfaces and colloids, 29(11), 3546-3555 (2013-01-17)
Systematic studies of silver particle deposition kinetics under diffusion transport on poly(allylamine hydrochloride) (PAH) modified mica were carried out. Monolayer coverage, quantitatively determined by AFM and SEM, was regulated within broad limits by adjusting the deposition time and the ionic
Biotechnology and bioengineering, 110(2), 586-596 (2012-08-14)
Alignment of skeletal myoblasts is considered a critical step during myotube formation. The C2C12 cell line is frequently used as a model of skeletal muscle differentiation that can be induced by lowering the serum concentration in standard culture flasks. In
The mechanism of the cellular uptake of polyelectrolyte microcapsules and its influences on the functions and toxicity of human SMCs are explored. The covalently assembled poly(allylamine hydrochloride)/glutaraldehyde microcapsules are easily ingested by SMCs mainly through macropinosis and caveolae-mediated endocytosis pathways.
Biologic wound dressings contain animal-derived components and are susceptible to high infection rates. To address this issue, we report an approach that permits incorporation of non-toxic levels of the small molecule antiseptic 'chlorhexidine' into biologic dressings. The approach relies on
We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.
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